April 22, 2014
Hello! I don’t know how much blogging I’ll be able to do on this trip, but I thought I’d give it a try, at least to get started. Currently I’m on a public computer in the Hong Kong Airport, waiting for a flight to Kathmandu. I’ve linked up with 5 fellow travelers from UC Davis (one of whom, John Rose, is a classmate from medical school), and we will begin trekking on Thursday heading for Everest Base Camp, if all goes according to plan. However, there was a major catastrophe last Friday, when an icefall triggered an avalanche that killed at least 13 people, most of whom were Sherpas, the legendary people who live near Everest and do almost all of the “grunt work” (marking trails and carrying most of the gear in support of climbing expeditions). They were beyond Base Camp, but the Sherpas are considering going on strike, and if they do, our little trek may not happen.
I’ll say more when I know more & will try to update from Kathmandu, where we’ll be staying in the Yak & Yeti Hotel (I love that name).
Franklin Perry, MD
Introduction: Why “Rainbow”?
Many have asked about our name, e.g. are you gay? Or hippie? Woo woo? The answer is none of the above. Rainbows symbolize the relief we feel when we see such a beautiful signal of the end of a storm, when the sun is breaking through. Rainbows also suggest inclusiveness, diversity, the “pot of gold”, and (from the Old Testament) renewal and redemption. Continue reading
A Smooth Landing vs. “Crash and Burn”: The Exit Strategy for Chronic Pain Patients
An ASAM presentation by Herbert Malinoff, MD
Pain & Addiction: Common Threads XI April 16, 2010
Reviewed by Franklin Perry, M.D., Ph.D.
· Dr. Malinoff, the Medical Director of Pain Recovery Solutions and Clinical Faculty at the U of Michigan Medical Center presented this masterful and thought-provoking talk at the recent ASAM meetings in San Francisco about the exceptionally challenging topic of how to manage the situation in which a person is taking high doses of opioids and still experiencing significant pain.
· There are many cannabis species and >460 known chemical constituents. ∆9 THC is the principal psychoactive component.
· Therapeutic properties of cannabis were described as early as 200 A.D. in Chinese medicine writings.
· Cannabinol was discovered and synthesized in 1940.
· THC was discovered in 1960 by Dr. Mechoulam of Hebrew University.
· THC binding sites in the nervous system were discovered in 1988.
· The first cannabinoid (CB) receptor (CB1) was cloned in 1990.
· The first endocannabinoid (eCB) was identified in Mechoulam & Partwee (Scotland) in 1992 and named anandamide from the Sanskrit word “anand” (bliss).
· The CB2 receptor was cloned in 1993.
· A 2nd eCB was discovered in 1995 and called 2-AG (2-Arachidonoylglycerol).
· Dr. Gardner and other scientists fully expect the discovery of new eCB receptors, eCBs, eCB enzymes, and therapies.